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In vitro and in vivo analysis of endothelial progenitor cells from cryopreserved umbilical cord blood: are we ready for clinical application?

In vitro and in vivo analysis of endothelial progenitor cells from cryopreserved umbilical cord blood: are we ready for clinical application?

Umbilical cord blood (CB) represents a main source of circulating endothelial progenitor cells (cEPCs). In view of their clinical use, in both the autologous or allogeneic setting, cEPCs should likely be expanded from CB kept frozen in CB banks. In this study, we compared the expansion, functional features, senescence pattern over culture and in vivo angiogenic potential of cEPCs isolated from fresh or cryopreserved CB (cryoCB).

Authors: Valrie Vanneaux, Fida El-Ayoubi *, Catherine Delmau *, Catherine Driancourt, Sverine Lecourt, Aurore Grelier, Audrey Cras, Wendy Cuccuini, Jean Soulier, Jean-Jacques Lataillade, Marie-Caroline Lebousse-Kerdiles, Jean Franois Oury, Olivier Sibony, Jean-Pierre Marolleau, Marc Benbunan, Georges Uzan, and Jrme Larghero

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Date 14 February 2017
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